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What is the Difference Between Agonists and Antagonists?

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Question

 What is the difference between agonists and antagonists? 

Distinguish Between
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Solution

Agonists           Drugs that mimic the natural 
Drugs that mimic the natural  Drugs that bind to the receptor site and 
messenger by switching on the inhibit its natura receptor. inhibit its natural function are called Antagonists. 
Useful when there is lack of natural chemical messenger. Useful when  blocking of messege in required
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2018-2019 (March) 56/3/2

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Which of the following statements are incorrect about receptor proteins?

(i) Majority of receptor proteins are embedded in the cell membranes.

(ii) The active site of receptor proteins opens on the inside region of the cell.

(iii) Chemical messengers are received at the binding sites of receptor proteins.

(iv) Shape of receptor doesn’t change during attachment of messenger.


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How are receptor proteins located in the cell membrane?


Match the class of compounds given in Column I with their functions given in Column II.

Column I Column II
(i) Antagonists (a) Communicate message between two neurons and that between neurons to muscles
(ii) Agonists (b) Bind to the receptor site and inhibit its natural function
(iii) Chemical messenger (c) Crucial to body’s communication process
(iv) Inhibitors (d) Mimic the natural messenger
(v) Receptors (e) Inhibit activities of enzymes

Assertion: Chemical messengers are chemicals that enable communication of message between two neurons or between neurons and muscles.

Reason: Chemicals enter the cell through receptor.


Assertion: Chemical messenger gives message to the cell without entering the cell.

Reason: Chemical messenger is received at the binding site of receptor proteins.


Assertion: Receptor proteins show selectivity for one chemical messenger over the other.

Reason: Chemical messenger binds to the receptor site and inhibits its natural function.


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