Question

What are non-histone chromosomal (NHC) proteins?

Options

• Enzymes that synthesise DNA during replication

• Proteins that transport DNA across the nuclear envelope

• The five main histone types found in eukaryotic nuclei

• Proteins other than histones that are associated with chromatin and help in higher-order DNA packaging and regulation

Answer 1

Non-histone chromosomal (NHC) proteins form a heterogeneous collection of proteins distinct from histones that associate with chromatin. They form the structural scaffold to which DNA loops are anchored during higher-order compaction and regulate critical processes such as DNA replication, RNA synthesis, and other nuclear functions.