Question

Malonate inhibits the growth of pathogenic bacteria by inhibiting the activity of ______.

Options

• Amylase

• Lipase

• Dinitrogenase

• Succinic dehydrogenase

Answer 1

Malonate inhibits the growth of pathogenic bacteria by inhibiting the activity of succinic dehydrogenase.

Explanation:

Succinic dehydrogenase is an enzyme found in bacteria that contributes to electron transport in the TCA cycle. This enzyme converts succinate to fumarate, contributing significantly to energy production. Melonate is a competitive inhibitor of succinic dehydrogenase. It competes with succinate to attach to the enzyme's active site due to its structural similarity. Binding inhibits enzymes and interrupts the TCA cycle and electron transport chain, resulting in decreased ATP synthesis and preventing harmful bacteria from developing.