Question

Is aminoacylation an endothermic or exothermic reaction?

Options

• Thermodynamically neutral

• Isothermic (no energy change)

• Exothermic (releases energy)

• Endothermic (requires energy)

Answer 1

Aminoacylation is an endothermic reaction that requires energy input. The energy comes from ATP hydrolysis during the formation of the aminoacyl-tRNA. This high-energy charged tRNA product makes the subsequent peptide bond formation thermodynamically favourable during translation.