Question

In prokaryotic DNA compaction, the looping step creates how many loop domains?

Options

• 100–150 loop domains

• 40–50 loop domains

• 1–10 loop domains

• 200–300 loop domains

Answer 1

During the looping step of prokaryotic DNA compaction, 40–50 loop domains are formed, assisted by RNA connectors. This looping reduces the DNA diameter from ~350 µm to approximately 30 micrometres and is a critical intermediate step before the final supercoiling stage.