Question

In eukaryotes, how does DNA replication terminate?

Options

• When a single Ter site is reached

• When adjacent replicons fuse after replication forks from different origins merge

• When topoisomerase prevents further supercoiling

• When Okazaki fragments cease to be synthesised

Answer 1

In eukaryotes, multiple replication forks travel in both directions from multiple origins of replication simultaneously. Termination occurs when replication forks from adjacent replicons meet and fuse, rather than at a single termination site. This allows eukaryotic chromosomes to replicate efficiently.