Question

Distinguish between Intrinsic and extrinsic process of clotting

Answer 1

Intrinsic pathway	Extrinsic pathway
1. It is stimulated by damage to blood vessels.	1. It is stimulated by damage to tissue outside the vessel.
2. It is more complex and takes more time than the extrinsic pathway.	2. It occurs rapidly as it has fewer steps as compared to the intrinsic pathway.
3. Tissue factor is not involved in the activation of the intrinsic pathway.	3. Tissue factor also known as thromboplastin activates extrinsic pathways.
4. It involves factor VIII, IX, XI, and XII.	4. It involves factors VII, X, and V.