Question

Differentiate between thalassemia and sickle cell anaemia on the basis of their effect on globin molecule of Haemoglobin.

Answer 1

Thalassemia: Mutations or deletions in genes encoding alpha or beta globin chains result in reduced or missing globin production.

Sickle Cell Anaemia: A point mutation in the B-globin gene (HBB) replaces glutamic acid with valine at position 6, leading to aberrant hemoglobin (HbS) and sickle-shaped red blood cells.