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Question
Differentiate between Somatic cell gene therapy and germline gene therapy.
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Solution
| Somatic Cell Gene Therapy | Germ Line Gene Therapy |
| 1. Therapeutic genes transferred into the somatic cells. | 1. Therapeutic genes transferred into the germ cells. |
| 2. Introduction of genes into bone marrow cells, blood cells, skin cells, etc. | 2. Genes introduced into eggs and sperms. |
| 3. It Will not be inherited in later generations. | 3. It Will not be inherited in later generations. |
RELATED QUESTIONS
Gene therapy is an attempt to correct a Genetic defect by providing a normal gene into the individual. By this the function can be restored. An alternate method would be to provide gene product known as enzyme replacement therapy, which would also restore the function. Which in your opinion is a better option? Give reasons for your answer.
ADA-SCID treatment in lymphocytes is an example of which type of therapy based on target cell?
After the defective gene is identified, what occurs next in the ex vivo method?
What results when the functional gene is expressed after gene therapy?
Adenosine deaminase (ADA) deficiency causes which condition?
From where are lymphocytes extracted in the ADA deficiency procedure?
Which vector is used to insert the functional ADA gene in the ADA deficiency procedure?
Why does the ADA deficiency procedure need periodic repetition?
Which additional genetic disorders are specifically listed as treatable by gene therapy?
What ethical concern is raised by Germ-Line Therapy?
