Question

Assertion (A): The hormone insulin consists of two short polypeptide chains, chain A and chain B, which are linked together by diphosphate bridges.

Reason (R): Insulin is first synthesised as a pro-enzyme. The hormone has an extra stretch of peptide called the C-peptide.

Options

• Both assertion (A) and reason (R) are true, and reason is the correct explanation of assertion.

• Both assertion (A) and reason (R) are true, but reason is not the correct explanation of assertion.

• Assertion (A) is true but reason (R) is false.

• Both assertion (A) and reason (R) are false.

Answer 1

Both assertion (A) and reason (R) are false.

Explanation:

Insulin’s A and B chains are linked by disulphide bridges, not diphosphate bridges. Insulin is first synthesised as a pro-hormone, not a pro-enzyme; it contains an extra C-peptide that is removed during maturation.