Question

Differentiate between Glycolysis and Krebs’ cycle.

Differentiate between Glycolysis and Citric acid Cycle.

Answer 1

	Glycolysis	Krebs' cycle (Citric acid Cycle)
1.	It takes place within the cytoplasm.	The Kreb's cycle functions within the mitochondria.
2.	The first stage of respiration, known as glycolysis, breaks down glucose to produce pyruvate.	The second stage of respiration, known as Kreb's cycle, is when an active acetyl group is fully broken down.
3.	Both the aerobic and anaerobic modes of respiration use the same procedure.	It only happens during aerobic respiration.
4.	It breaks down a glucose molecule into two pyruvate molecules, an organic material.	Pyruvate is entirely broken down into organic matter (CO2 + H2O).
5.	Two ATP molecules are used by glycolysis to phosphorylate the substrate molecule once.	ATP is not used by it.
6.	During glycolysis, phosphorylation at the substate level releases four ATP molecules from one glucose molecule.	Through substrate-level phosphorylation, two acetyl residues release two ATP or GTP molecules in Kreb's cycle.
7.	For each glucose molecule broken down, there is a net gain of two molecules of NADH and two molecules of ATP.	For every two molecules of acetyl CoA that the Krebs cycle oxidises, it produces two molecules of FADH2 and six molecules of NADH. Two pyruvates are converted to acetyl CoA, releasing two molecules of NADH in the process.
8.	The energy gained net is equivalent to 8 ATP.	The total energy gained is equivalent to 24 ATP molecules. Two NADH2 molecules created when two pyruvates are dehydrogenated can provide six ATP molecules.
9.	In glycolsis, no carbon dioxide is produced.	The Krebs cycle produces carbon dioxide.
10.	Glycolysis does not require oxygen.	As the terminal oxidant in the Krebs cycle, oxygen.