Question

Write a note on Down’s syndrome.

Answer 1

Down syndrome:

1. Individuals suffering from Down syndrome will have 47 chromosomes instead of the normal number 46.
2. 21st Trisomy occurs due to non-disjunction or failure of separation of chromosomes (autosomes) during gamete formation.
3. Following are the symptoms of Down syndrome:

1. Mild or moderate mental retardation and poor skeletal development.
2. Distinct facial features like small head, ears, and mouth.
3. The face is typically flat and rounded with a flat nose, open mouth, and protruding tongue.
4. Eyes slant up and out with internal epicanthal folds.
5. Flat hands and stubby fingers, the palm is broad with a single palmer crease.