Question

When declining levels of estrogens and progesterone stimulate secretion of GnRH, is this a positive or negative feedback effect and why?

Answer 1

When declining levels of estrogens and progesterone stimulate secretion of GnRH, this is a negative feedback effect. It is negative because the response is opposite to the stimulus; decreasing hormones cause GnRH release, which then raises FSH and LH to eventually increase estrogen secretion again, maintaining hormonal balance. This feedback regulates the menstrual cycle by controlling hormone levels appropriately.