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प्रश्न
What are recombinant DNA vaccines? Give two examples of such vaccines. Discuss their advantages.
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उत्तर
A recombinant vaccine is a vaccine produced through recombinant DNA technology. This involves inserting the DNA encoding an antigen that stimulates an immune response into bacterial or mammalian cells. Recombinant DNA technology has allowed the production of antigenic polypeptides of pathogen in bacteria or yeast. Vaccines produced using this approach allow large-scale production and hence greater availability for immunisation, e.g., hepatitis B vaccine (Recombivax HB) produced from yeast. As of June 2015 one human DNA vaccine had been approved for human use, the single-dose Japanese encephalitis vaccine called IMOJEV, released in 2010 in Australia.
Advantages of recombinant DNA vaccines:
- No risk for infection
- Ease of development and production
- Stability for storage and shipping
- Cost-effectiveness
- Expression and purification of recombinant proteins
- Long-term persistence of immunogen
- In vivo expression ensures protein more closely resembles normal eukaryotic structure, with accompanying post-translational modifications.
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संबंधित प्रश्न
What is vaccine?
Define the following:
Immunisation
Mention the contributions of
Edward Jenner
Mention the contributions of
Louis Pasteur.
How vaccination helps to prevent diseases?
What are antibiotics?
The principle of vaccination is to produce immunity against a disease. Explain.
Select the most appropriate option in each case.
Vaccines are
Given below are the groups of certain substances of particular categories. Mention the category of each group and identify the wrong example giving reason.
Tears, skin, nasal secretion, HCl (in stomach)
Differentiate between : Vaccination and sterilisation
What is vaccination?
Expand the following.
WHO-
Pick out the odd one.
What is triple antigen? Mention the disease which can be prevented by using the antigen.
Injecting a person with globulins against a disease like hepatitis confers ______.
In human beings, antibodies are used to cure infectious diseases like cholera, typhoid, etc.
Define the following:
Infection
What is NOT true about the purpose of vaccination?
Assertion: A person who has received a cut from a sharp object and is bleeding, needs to be given an anti-tetanus injection.
Reason: Anti-tetanus injection stimulates the production of antibodies for tetanus.
