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प्रश्न
What are recombinant DNA vaccines? Give two examples of such vaccines. Discuss their advantages.
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उत्तर
A recombinant vaccine is a vaccine produced through recombinant DNA technology. This involves inserting the DNA encoding an antigen that stimulates an immune response into bacterial or mammalian cells. Recombinant DNA technology has allowed the production of antigenic polypeptides of pathogen in bacteria or yeast. Vaccines produced using this approach allow large-scale production and hence greater availability for immunisation, e.g., hepatitis B vaccine (Recombivax HB) produced from yeast. As of June 2015 one human DNA vaccine had been approved for human use, the single-dose Japanese encephalitis vaccine called IMOJEV, released in 2010 in Australia.
Advantages of recombinant DNA vaccines:
- No risk for infection
- Ease of development and production
- Stability for storage and shipping
- Cost-effectiveness
- Expression and purification of recombinant proteins
- Long-term persistence of immunogen
- In vivo expression ensures protein more closely resembles normal eukaryotic structure, with accompanying post-translational modifications.
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संबंधित प्रश्न
What is vaccine?
Write short (2-3 sentences) note on vaccination.
Define the following:
Immunisation
Name three commonly used vaccines.
Given below are the groups of certain substances of particular categories. Mention the category of group and identify the wrong example giving reason.
BCG, DTP, ATP
Given below are the groups of certain substances of particular categories. Mention the category of each group and identify the wrong example giving reason.
Tears, skin, nasal secretion, HCl (in stomach)
Expand the following.
WHO-
Suggest the immunization schedule for a new born baby till 12 months of age. Why it is necessary to follow the schedule?
The typhoid vaccine which is administered orally is ______
In the given structure of an antibody molecule, identify the label 'X'.
Antibodies of white polio drops that are administered into the body contain:
The disease that is eliminated totally by the vaccination process is ______.
In human beings, antibodies are used to cure infectious diseases like cholera, typhoid, etc.
What is an immunization?
What is TAB?
Assertion: A person who has received a cut from a sharp object and is bleeding, needs to be given an anti-tetanus injection.
Reason: Anti-tetanus injection stimulates the production of antibodies for tetanus.
Which of the following best describes the process of administering a vaccine to stimulate the immune system and provide protection against infectious diseases?
What is the primary function of antibodies produced in response to vaccine antigens during an actual infection?
Which statement accurately describes immunisation?
When a vaccine response occurs in the body, which type of immune response is built?
