Advertisements
Advertisements
प्रश्न
What are recombinant DNA vaccines? Give two examples of such vaccines. Discuss their advantages.
Advertisements
उत्तर
A recombinant vaccine is a vaccine produced through recombinant DNA technology. This involves inserting the DNA encoding an antigen that stimulates an immune response into bacterial or mammalian cells. Recombinant DNA technology has allowed the production of antigenic polypeptides of pathogen in bacteria or yeast. Vaccines produced using this approach allow large-scale production and hence greater availability for immunisation, e.g., hepatitis B vaccine (Recombivax HB) produced from yeast. As of June 2015 one human DNA vaccine had been approved for human use, the single-dose Japanese encephalitis vaccine called IMOJEV, released in 2010 in Australia.
Advantages of recombinant DNA vaccines:
- No risk for infection
- Ease of development and production
- Stability for storage and shipping
- Cost-effectiveness
- Expression and purification of recombinant proteins
- Long-term persistence of immunogen
- In vivo expression ensures protein more closely resembles normal eukaryotic structure, with accompanying post-translational modifications.
APPEARS IN
संबंधित प्रश्न
What is vaccine?
Given below is a table of certain vaccines, the diseases against which they are used and the nature of vaccine. Fill up the gaps 1-10.
|
Vaccine |
Disease(s) |
The Nature of Vaccine |
|
TAB |
1. _______________ |
2. ___________________ |
|
Salk's vaccine |
3. _______________ |
4. ___________________ |
|
BCG |
5. _______________ |
Living weakened germs |
|
Vaccines for measles |
Measles |
6. ___________________ |
|
Cowpox virus |
7. _______________ |
8. ___________________ |
|
Toxoids |
9. _______________ |
Extracts of toxins |
|
|
10. ______________ |
Secreted by bacteria |
Mention if the following statement is true (T) or false (F).
Vaccine provides the body with active immunity.
What is vaccination?
Expand the following.
WHO-
State whether true or false. If false, correct the statement.
The process of vaccination was developed by Jenner.
Define the following.
Vaccines
What is triple antigen? Mention the disease which can be prevented by using the antigen.
The typhoid vaccine which is administered orally is ______
In the given structure of an antibody molecule, identify the label 'X'.
The disease that is eliminated totally by the vaccination process is ______.
In human beings, antibodies are used to cure infectious diseases like cholera, typhoid, etc.
The oral polio vaccine is a killed vaccine.
Expand the following:
OPV –
What is TAB?
What is NOT true about the purpose of vaccination?
Assertion: A person who has received a cut from a sharp object and is bleeding, needs to be given an anti-tetanus injection.
Reason: Anti-tetanus injection stimulates the production of antibodies for tetanus.
