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प्रश्न
What are recombinant DNA vaccines? Give two examples of such vaccines. Discuss their advantages.
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उत्तर
A recombinant vaccine is a vaccine produced through recombinant DNA technology. This involves inserting the DNA encoding an antigen that stimulates an immune response into bacterial or mammalian cells. Recombinant DNA technology has allowed the production of antigenic polypeptides of pathogen in bacteria or yeast. Vaccines produced using this approach allow large-scale production and hence greater availability for immunisation, e.g., hepatitis B vaccine (Recombivax HB) produced from yeast. As of June 2015 one human DNA vaccine had been approved for human use, the single-dose Japanese encephalitis vaccine called IMOJEV, released in 2010 in Australia.
Advantages of recombinant DNA vaccines:
- No risk for infection
- Ease of development and production
- Stability for storage and shipping
- Cost-effectiveness
- Expression and purification of recombinant proteins
- Long-term persistence of immunogen
- In vivo expression ensures protein more closely resembles normal eukaryotic structure, with accompanying post-translational modifications.
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संबंधित प्रश्न
Write short (2-3 sentences) note on immunisation.
Write short (2-3 sentences) note on vaccination.
What is vaccination? Mention the four ways in which vaccine’s are prepared, giving the name of one disease for which each type of vaccine is used.
Mention the contributions of
Edward Jenner
How vaccination helps to prevent diseases?
Fill in the blank:
Lack of insulin may lead to ................
Select the most appropriate option in each case.
'T' in DTP vaccination stands for
Select the most appropriate option in each case.
DPT stands for
Select the most appropriate option in each case.
Vaccines are
Given below is a table of certain vaccines, the diseases against which they are used and the nature of vaccine. Fill up the gaps 1-10.
|
Vaccine |
Disease(s) |
The Nature of Vaccine |
|
TAB |
1. _______________ |
2. ___________________ |
|
Salk's vaccine |
3. _______________ |
4. ___________________ |
|
BCG |
5. _______________ |
Living weakened germs |
|
Vaccines for measles |
Measles |
6. ___________________ |
|
Cowpox virus |
7. _______________ |
8. ___________________ |
|
Toxoids |
9. _______________ |
Extracts of toxins |
|
|
10. ______________ |
Secreted by bacteria |
Given below are the groups of certain substances of particular categories. Mention the category of group and identify the wrong example giving reason.
BCG, DTP, ATP
Pick out the odd one.
State whether true or false. If false, correct the statement.
The process of vaccination was developed by Jenner.
What is triple antigen? Mention the disease which can be prevented by using the antigen.
The typhoid vaccine which is administered orally is ______
In the given structure of an antibody molecule, identify the label 'X'.
What is TAB?
After vaccination, the body builds up ______.
What is NOT true about the purpose of vaccination?
