Advertisements
Advertisements
प्रश्न
What are recombinant DNA vaccines? Give two examples of such vaccines. Discuss their advantages.
Advertisements
उत्तर
A recombinant vaccine is a vaccine produced through recombinant DNA technology. This involves inserting the DNA encoding an antigen that stimulates an immune response into bacterial or mammalian cells. Recombinant DNA technology has allowed the production of antigenic polypeptides of pathogen in bacteria or yeast. Vaccines produced using this approach allow large-scale production and hence greater availability for immunisation, e.g., hepatitis B vaccine (Recombivax HB) produced from yeast. As of June 2015 one human DNA vaccine had been approved for human use, the single-dose Japanese encephalitis vaccine called IMOJEV, released in 2010 in Australia.
Advantages of recombinant DNA vaccines:
- No risk for infection
- Ease of development and production
- Stability for storage and shipping
- Cost-effectiveness
- Expression and purification of recombinant proteins
- Long-term persistence of immunogen
- In vivo expression ensures protein more closely resembles normal eukaryotic structure, with accompanying post-translational modifications.
APPEARS IN
संबंधित प्रश्न
Put a tick mark (✓) against the correct alternative in the following statement:
Infectious diseases can be prevented by:
- Medicines
- Proper food
- Immunisation
- Exercise
How vaccination helps to prevent diseases?
What are antibiotics?
Fill in the blank:
Lack of insulin may lead to ................
The principle of vaccination is to produce immunity against a disease. Explain.
Select the most appropriate option in each case.
Vaccines are
Mention if the following statement is true (T) or false (F).
Vaccine provides the body with active immunity.
Make a list of the vaccinations that are given to a newborn baby.
Intestinal diseases spread through air.
Pick out the odd one.
State whether true or false. If false, correct the statement.
The process of vaccination was developed by Jenner.
In human beings, antibodies are used to cure infectious diseases like cholera, typhoid, etc.
The oral polio vaccine is a killed vaccine.
Define the following:
Infection
After vaccination, the body builds up ______.
What is NOT true about the purpose of vaccination?
