Question

Answer the following question.
Both Haemophilia and Thalessemia are blood-related disorders in humans. Write their causes and the difference between the two. Name the category of genetic disorder they both come under.

Answer 1

Both are Mendelian disorders.

• Haemophilia is a sex-linked recessive disorder. The gene for haemophilia is located on X-chromosome. The gene passes from a carrier female to her son.
• Thalessemia is an autosomal linked recessive disease.
• It occurs due to either mutation or deletion resulting in reduced rate of synthesis of one of the globin chains of haemoglobin
• The difference between Haemophilia and Thalessemia is: -In haemophilia, clotting is affected, i.e. there can be a non-stop bleeding even after a minor cut.
• In Thalessemia, anaemia is the characteristic of this disease.