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प्रश्न
Which structural chromosomal abnormality is exemplified by the Philadelphia chromosome associated with Chronic Myeloid Leukaemia?
विकल्प
Translocation
Deletion
Duplication
Inversion
MCQ
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उत्तर
The Philadelphia chromosome represents a translocation in which a segment from chromosome 9 attaches to chromosome 22. This balanced translocation t(9;22) causes the fusion of the BCR and ABL genes, leading to abnormal protein production and Chronic Myeloid Leukaemia. Carriers may appear phenotypically normal but have increased cancer risk.
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