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प्रश्न
What condition is characterized by the presence of the Philadelphia chromosome?
विकल्प
Chronic Myeloid Leukaemia
Acute Lymphoblastic Leukaemia
Multiple Myeloma
Hodgkin's Lymphoma
MCQ
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उत्तर
The Philadelphia chromosome (translocation t(9;22) involving the fusion of chromosome 9 and 22) is characteristic of Chronic Myeloid Leukaemia. This balanced translocation results in the BCR-ABL fusion gene, which produces a constitutively active tyrosine kinase protein that drives cancer development. It is found in approximately 95% of CML cases.
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