Question

State the role of pancreatic juice in digestion of proteins.

Answer 1

Pancreatic juice contains a variety of inactive enzymes such as trypsinogen, chymotrypsinogen, and carboxypeptidases. These enzymes play an important role in the digestion of proteins.

Physiology of protein-digestion

The enzyme enterokinase is secreted by the intestinal mucosa. It activates trypsinogen into trypsin.

Trypsinogen  Trypsin + Inactive peptide

Trypsin then activates the other enzymes of pancreatic juice such as chymotrypsinogen and carboxypeptidase.

Chymotrypsinogen is a milk-coagulating enzyme that converts proteins into peptides.

Chymotrypsinogen  Chymotrypsin

(Inactive)                                        (Active)

Proteins Peptides

Carboxypeptidase acts on the carboxyl end of the peptide chain and helps release the last amino acids. Hence, it helps in the digestion of proteins.

Peptides  Smaller peptide chain + Amino acids

Thus, in short, we can say that the partially-hydrolysed proteins present in the chyme are acted upon by various proteolytic enzymes of the pancreatic juice for their complete digestion.

Proteins, peptones Dipeptides and proteases

Answer 2

The pancreatic juice contains inactive enzymes – trypsinogen, chymotrypsinogen, procarboxypeptidases. Trypsinogen is acti¬vated by an enzyme enterokinase, (secreted by the intestinal mucosa) into active trypsin, which in turn activates the other enzymes of the pancreatic juice. Proteins, proteoses and peptones (partially hydrolysed proteins) in the chyme reaching the intestine are acted upon by these proteolytic enzymes of pancreatic juice.