Question

Name the genetic disorder caused by trisomy of 21^st chromosome in humans. Write the diagnostic features of the disorder.

Answer 1

The genetic disorder caused by trisomy of the 21st chromosome in humans is Down’s syndrome. Diagnostic features include mental retardation, prominent forehead, flattened nasal bridge, open mouth, protruding lower lips, large protruding tongue, a skin fold at the eye corner, short fingers, a single palm crease, and often congenital heart defects. The baby is usually floppy when handled and has a happy disposition with a great sense of humor.