Question

How is gene therapy carried out to treat the patients suffering from ADA deficiency disease?

Answer 1

The immune system’s ability to function depends heavily on ADA. Severe mixed immunodeficiency disease results from an ADA deficiency. The patient is unable to combat the pathogenic germs because they lack functional T-lymphocytes. Gene therapy involves removing cells from the patient’s bone marrow and using the retrovirus to insert a normal, functional gene for ADA into the lymphocytes. The functioning ADA gene is present in bone marrow cells, which reawaken the patient’s immune system.