Drug-target Interaction - Enzymes as Drug Targets

Name the macromolecules that are chosen as drug targets.

How do enzymes catalyse a chemical reaction in the living system? Explain drug target interaction taking the example of enzyme as target.

What are enzyme inhibitors? Classify them on the basis of their mode of attachments on the active site of enzymes. With the help of diagrams explain how do inhibitors inhibit the enzymatic activity.

Assertion: Enzymes have active sites that hold substrate molecule for a chemical reaction.

Reason: Drugs compete with natural substrate by attaching covalently to the active site of enzyme.

Explain the role of allosteric site in enzyme inhibition?

Which of the following statements is correct?

Which forces are involved in holding the drugs to the active site of enzymes?

Assertion: Non-competitive inhibitor inhibits the catalyic activity of enzyme by binding with its active site.

Reason: Non-competitive inhibitor changes the shape of the active site in such a way that substrate can’t recognise it.