Question

The phenomenon known as wobble refers to ______.

पर्याय

• The movement of multiple ribosomes along the same mRNA.

• The shifting of the reading frame in a deletion or insertion mutation.

• The ability of a tRNA to pair with different codons that may differ in the third base.

• The movement of a tRNA from the A to the P site.

Answer 1

The phenomenon known as wobble refers to the ability of a tRNA to pair with different codons that may differ in the third base.

Explanation:

The Wobble Hypothesis, proposed by Francis Crick, explains how a single transfer RNA (tRNA) molecule can recognise and bind to more than one messenger RNA (mRNA) codon. While the first two bases of a codon pair strictly with the anticodon according to standard Watson-Crick rules (A-U, G-C), the pairing at the third base position is more flexible or “wobbles”. This non-standard pairing allows a cell to translate all 61 sense codons using a much smaller number of tRNA types (around 40), making protein synthesis more efficient.