Definitions [2]
Define:
a. Analgesics
b. Antimicrobials
a. Analgesics: The drugs which relieve pain by acting on the central nervous system without loss of consciousness or disturbance of the nervous system are called analgesics.
b. Antimicrobials:
The drugs used to kill or stop the growth of micro-organisms like fungi, bacteria, and virus are called antimicrobial drugs.
Define Broad-spectrum antibiotics with a suitable example?
The antibiotics which are effective against a wide range of gram-positive and gram-negative bacteria are known as broad spectrum antibiotics.
Examples: Chloramphenicol, ampicillin, amoxicillin
Limited spectrum antibiotics: Antibiotics which are effective against a single organism or disease are called limited-spectrum antibiotics
Key Points
Antimicrobials are drugs that kill or inhibit microorganisms (bacteria, viruses, fungi)
Types of Antimicrobials:
| Type | Where Used | Action | Examples |
|---|---|---|---|
| Antibiotics | Internal use | Selective toxicity (kills microbes, not host); produced by microorganisms | Penicillin, chloramphenicol |
| Antiseptics | Applied to living tissues | Prevent infection (safe for skin) | Dettol, iodine |
| Disinfectants | Applied to non-living surfaces | Kill wide range of microbes | Phenol |
Spectrum of Antibiotics:
| Type | Effective Against |
|---|---|
| Broad spectrum | Many bacteria |
| Narrow spectrum | Specific group |
| Limited spectrum | Single organism |
Cleansing agents are substances used to remove stain, dirt, or clutter from a surface.
Soaps:
- Soaps are sodium or potassium salts of long chain fatty acids
- Obtained by alkaline hydrolysis (saponification) of natural oils and fats with NaOH or KOH
- Reaction: Natural oil/fat + NaOH/KOH → Soap + Glycerol
- Example: Sodium stearate (C₁₇H₃₅COONa)
- Chemically, soaps are triesters of long chain fatty acids and propan-1,2,3-triol (commonly called glycerol or glycerin)
Synthetic Detergents:
Synthetic detergents work in hard water (unlike soaps). Three types:
| Type | Example | Use |
|---|---|---|
| Anionic detergents | (Sodium lauryl sulphate) \[CH_3(CH_2)_{10}CH_2OSO_3^{\oplus}Na^{\oplus}\] | Household detergent, additive in toothpaste |
| Cationic detergents | \[\mathrm{CH_{3}(CH_{2})_{15}-N^{\oplus}(CH_{3})_{3}Br^{\oplus}}\] (Cetyltrimethyl ammonium bromide) | Hair conditioner, germicide |
| Non-ionic detergents |
\[CH_{3}\left(CH_{2}\right)_{16}-COO\left(CH_{2}CH_{2}O\right)_{n}CH_{2}CH_{2}OH\] (an ester) | Liquid dishwash |
| liquid detergent |
Concepts [13]
- Chemistry in Everyday Life
- Classification of Drugs
- Designing of a Drug and Action of Drugs on Targets
- Drug-target Interaction - Enzymes as Drug Targets
- Drug-target Interaction - Receptors as Drug Targets
- Therapeutic Action of Different Classes of Drugs - Neurologically Active Drugs
- Antimicrobials
- Therapeutic Action of Different Classes of Drugs - Antifertility Drugs
- Therapeutic Action of Different Classes of Drugs - Antacids
- Therapeutic Action of Different Classes of Drugs - Antihistamines
- Chemicals in Food - Artificial Sweetening Agents and Food Preservatives
- Cleansing Agents
- Preparation from Soap: Saponification
