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प्रश्न
Answer the following question.
Two children, A and B aged 4 and 5 years respectively visited a hospital with a similar genetic disorder. The girl A was provided enzyme-replacement therapy and was advised to revisit periodically for further treatment. The girl, B was, however, given a therapy that did not require revisit for further treatment.
Why did the treatment provided to girl A required repeated visits?
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उत्तर
Girl A was given Enzyme replacement therapy in which lymphocytes isolated from patient's blood are cultured in-vitro. Functional ADA cDNA is then introduced into the cultured lymphocytes. These lymphocytes are returned back to the patient's body. Lymphocytes are not immortal. Therefore, repeated infusion of genetically engineered lymphocytes is required and hence it is not a permanent treatment and the patient has to revisit periodically in the future.
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संबंधित प्रश्न
Answer the following question.
Two children, A and B aged 4 and 5 years respectively visited a hospital with a similar genetic disorder. The girl A was provided enzyme-replacement therapy and was advised to revisit periodically for further treatment. The girl, B was, however, given a therapy that did not require revisit for further treatment.
How was the girl B cured permanently?
What is the difference between missense and nonsense mutation?
The point mutation sequence for transition, transition, transversion, and transversion in DNA are
Rate of mutation is affected by ______.
Mutations result in
Match list I with list II
| List I | List II |
| A. A pair of chromosomes extra with diploid | (i) monosomy |
| B. One chromosome extra to the diploid | (ii) tetrasomy |
| C. One chromosome loses from diploid | (iii) trisomy |
| D. Two individual chromosomes lose from diploid | (iv) double monosomy |
What mechanism causes a frameshift mutation?
Which of the following is caused by intrinsic replication errors and tautomeric shifts?
Which physical mutagen works through ionizing radiation to break DNA strands?
Which physical mutagens are classified as ionizing radiation?
