BE Biotechnology Semester 5 (TE Third Year)University of Mumbai
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Bioreactor Analysis and Technology Semester 5 (TE Third Year) BE Biotechnology University of Mumbai Topics and Syllabus

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CBCGS [2018 - current]
CBGS [2014 - 2017]
Old [2000 - 2013]

Topics with syllabus and resources

100.00 Basic Reaction Kinetics
  • Reaction thermodynamics
  • Order and molecularity of reaction
  • Homogeneous and heterogeneous reactions
  • Elementary and non elementary reactions
  • Reaction yield
  • Reaction rate
  • Calculation of reaction rates from experimental data
  • General reaction kinetics for biological system
  • Production kinetics in cell culture
  • Kinetics of substrate uptake in cell culture
  • Growth kinetics with plasmid instability
200.00 Ideal Reactors
  • Constant volume and variable reactors
  • Batch operation of a well mixed enzyme and cell culture reactor
  • Fed batch operation of a well mixed enzyme and cell culture reactor
  • Continuous operation of well mixed enzyme and cell culture reactor
  • Continuous operation of plug flow enzyme and cell culture reactor
  • Autocatalytic reactions
  • Recycle reactors-plug flow reactor and continuous stirred tank reactor
  • Comparison between major modes of reactor operation
300.00 Multiple Reactors and Reaction Systems
  • Continuous stirred tank reactors of unequal size in series
  • Finding conversion in given system
  • Determining the best system for a given conversion
  • Plug flow reactors in series and parallel
  • Reactors of different types in series
  • Simple reactions
  • Stepwise reactions
  • Parallel reactions
  • Series reactions
  • Maximizing R in batch reactor
  • Plug flow reactor and continuous stirred tank reactor
  • Reactor choice for series reactions and series parallel reactions
  • Concepts of reversible reactions
400.00 Heterogeneous Reactions
  • Heterogeneous reactions in Bioprocessing
  • Concentration gradients and reaction rates in solid catalysts
  • Internal mass transfer and reactions
  • steady state mass balance (spherical geometry)
  • Concentration profile for first order kinetics
  • Concentration profile for zero order kinetics
  • Concentration profile for MichaelisMenten kinetics
  • Effectiveness factor and Thiele Modulus
  • External mass transfer
500.00 Deviations from Ideal Reactors
  • Concept of non ideality
  • Reasons of non ideality
  • RTD studies
  • F curve
  • C curve
  • E curve
  • Diagnosis of ills of flow reactors
  • Modeling of non ideal behaviour-dispersion model
  • Tanks in series model
600.00 Working Principle of Unconventional Reactors
  • Selection criterion for bioreactors
  • Bubble column
  • Air lift reactor
  • Fluidized bed reactor
  • Perfusion reactors
  • Membrane reactors
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