BE Biotechnology Semester 5 (TE Third Year)University of Mumbai

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Topics and Syllabus - BE Biotechnology Biophysics Semester 5 (TE Third Year) University of Mumbai

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CBCGS [2018 - current]
CBGS [2014 - 2017]
Old [2000 - 2013]

Topics with syllabus and resources

1 Introduction to Biophysics
  • Physicochemical properties of biological macromolecules and their complexes
  • Structural studies of Nucleic Acids
  • Proteins
  • lipids and Carbohydrates.
  • Approaches: Electron Microscopy, Atomic Force Microscopy, X ray Crystallography, NMR Spectroscopy.
2 Nucleic Acid Interactions
  • Different nucleic acid carrier proteins
  • Carrier RNA
  • snRNA
  • Interactions between DNA & protein
  • Zinc finger proteins
  • various nucleic acid binding proteins
  • Nuclear transport
3 Membrane Structure and Properties
  • The principles governing the structures of biological membrane
  • Twodimensional fluids
  • Assembly of membrane components
4 Protein Structural Study
  1. Proteins -
  • Intra and inter molecular forces
  • helix-coil transitions and protein folding in a thermodynamical context
  • Secondary Motifs
  • Tertiary Architecture and Quaternary Organization
  • crystallization
  • diffraction theory
  • phasing techniques and structure validation
5 Lipids and Their Interaction
  • Details of Lipid Structures
  • Lipoproteins and Glycolipids
  • High density (HDL) and low density (LDL) lipoprotein
  • energetics-structurefunction relationship in exchangeable apolipoproteins and lipoproteins
  • Disorder caused by saturated fat and cholesterol
  • Artereochlerosis
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