BE Biotechnology Semester 5 (TE Third Year)University of Mumbai
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Topics and Syllabus - BE Biotechnology Bioinformatics 1 Semester 5 (TE Third Year) University of Mumbai

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CBCGS [2018 - current]
CBGS [2014 - 2017]
Old [2000 - 2013]

Topics with syllabus and resources

1 Introduction to Bioinformatics
  • Types of biological data
  • Sequencing Methods: DNA (Maxim Gilbert Method, Sangers Method) & Protein (MS-MS Analysis), Genomic Sequencing
  • ESTs and SNPs
  • Applications of bioinformatics.
2 Databases
  • Types of databases
  • Based on storage techniques (Flat , Relational, Object Oriented)
  • Based on data (Primary, Secondary , Specialized)
  • Search engines:- Entrez & SRS Sequence databases: NCBI , EMBL , DDBJ
  • Structural databases : PDB
  • Protein Databases : PIR ,SWISS PROT
  • Other Databases : KEGG , TrEMBL , EBI
3 Alignment
  • Global Alignment
  • Local Alignment
  • Pair Wise Sequence Alignment
  • Dot Matrix Alignment
  • Dynamic programming Methods : Needleman Wunch Algorithm, Smith Waterman Algorithm
  • Heuristic Method : BLAST ,FASTA
  • Amino Acid Substitution Matrices: PAM , BLOSSUM
  • Multiple Alignment: CLUSTAL W
  • Phylogenetic Analysis.
4 Visualization
  • Methods for representing biological data, Rasmol, Swiss PDB, 3D Structure Viewers.
5 Proteins
  • Structure
  • Classification
  • Classification databases
  • Protein Structure prediction :-
  • Primary Structure Prediction
  • Secondary Structure Prediction
  • Tertiary Structure Prediction
  • Homology Modelling
  • Chao-Fasman Algorithm
  • Neural Networks
  • Ab-Initio Modelling
  • Fold recognition (Threading)
6 Drug
  • Drug discovery Markov chains
  • Hidden markov models.
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