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Write a Note on Multiple Alleles Considering Example of Human Blood Groups. - Deviations from Mendelism - Incomplete Dominance, Co-dominance, Multiple Alleles and Inheritance of Blood Groups, Pleiotropy

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Write a note on multiple alleles considering example of human blood groups.

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Solution

Multiple Allelism:
a. More than two alternative forms (alleles) of gene in a population occupying the same locus on a chromosome or its homologue are known as multiple alleles.
b. ABO blood group system in humans is an example of multiple allelism, because gene I exists in three allelic forms IA, IB and IO.
c. Here, allele IA codes for type A blood, allele IB codes for type B blood and allele IO codes for type O blood.
d. Allele IO is recessive to the alleles IA and IB.
e. Thus, with these three alleles, we can have 6 different genotypes and 4 different phenotypes for blood groups.

  Genotype Phenotype (Blood group)
1 IA IA or IA IO Type A
2 IB IB or IB IO Type B
3 IA IB Type AB
4 IO IO Type O
Concept: Deviations from Mendelism - Incomplete Dominance, Co-dominance, Multiple Alleles and Inheritance of Blood Groups, Pleiotropy
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