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How Did the Chemical Nature of the ‘Transforming Principle' Get Established? - Biology

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ConceptSearch for Genetic Material Properties of Genetic Material (DNA Versus RNA)

Question

How did the chemical nature of the ‘Transforming Principle' get established?

Solution

Oswald Avery, Colin MacLeod and Maclyn McCarty concluded that DNA is the hereditary material. They discovered that the protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation, so the transforming substance was not a protein or RNA. Digestion with DNase inhibits transformation; therefore, they concluded that DNA is the hereditary material.

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Solution How Did the Chemical Nature of the ‘Transforming Principle' Get Established? Concept: Search for Genetic Material - Properties of Genetic Material (DNA Versus RNA).
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