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How Did the Chemical Nature of the ‘Transforming Principle' Get Established? - Biology

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How did the chemical nature of the ‘Transforming Principle' get established?

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Solution

Oswald Avery, Colin MacLeod and Maclyn McCarty concluded that DNA is the hereditary material. They discovered that the protein-digesting enzymes (proteases) and RNA-digesting enzymes (RNases) did not affect transformation, so the transforming substance was not a protein or RNA. Digestion with DNase inhibits transformation; therefore, they concluded that DNA is the hereditary material.

Concept: Search for Genetic Material - Properties of Genetic Material (DNA Versus RNA)
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