Describe the connecting link between glycolysis and Krebs’ cycle.
a. Each pyruvic acid molecule formed in glycolysis undergoes oxidative decarboxylation (i.e. oxidation by dehydrogenation and decarboxylation by loss of CO2), to form Acetyl group (2C), which combines with Co-A to form Acetyl Co-A.
b. Thus, pyruvic acid is converted to Acetyl Co-A. This is called Acetylation of Pyruvate.
c. It involves several reactions, many enzymes and co-factors.
d. Hydrogen released combines with NAD to form reduced co-enzyme NADH2, which has the potential to form 3ATP in ETS.
e. In this process, CO2 is released.
f. Acetyl Co-A is a connecting link between glycolysis and Krebs cycle.
g. Summary is represented as:
2PA+2 Co-A+2NAD`"Enzyme Complex (pyruvic dehydrogenase)"/""`2Acetyl Co-A+2CO2↑+2NADH2