Write short notes on Acetylation
Acetylation - Acetylation (or ethanoylation) is the process of introducing an acetyl group into a molecule.
Aliphatic and aromatic primary and secondary amines undergo acetylation reaction by nucleophilic substitution when treated with acid chlorides, anhydrides or esters. This reaction involves the replacement of the hydrogen atom of −NH2 or > NH group by the acetyl group, which in turn leads to the production of amides. To shift the equilibrium to the right hand side, the HCl formed during the reaction is removed as soon as it is formed. This reaction is carried out in the presence of a base (such as pyridine) which is stronger than the amine.
When amines react with benzoyl chloride, the reaction is also known as benzoylation.